Regulates Protein Synthesis (via S6K1, 4E-BP1) Regulates Lipid Synthesis Regulates mitochondrial metabolism (O2 Consumption, biogenesis) Backlinks Fasting Inhibits mtorc1 Insulin Like Growth Factor strongly increase mtorc1 activity Insulin increases mtorc1 activity Kefir activate mtorc2 while inhibiting mtorc1 causing longevity Leucine Most potent amino acid activator of mtorc1 Mechanistic Target of Rapamycin mtorc1 Rapamycin Decreases mtorc1 activity by binding to it