• Regulates Protein Synthesis (via S6K1, 4E-BP1)
• Regulates Lipid Synthesis
• Regulates mitochondrial metabolism (O2 Consumption, biogenesis)

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• Fasting
  
  • Inhibits mtorc1
• Insulin Like Growth Factor
  
  • strongly increase mtorc1 activity
• Insulin
  
  • increases mtorc1 activity
• Kefir
  
  • activate mtorc2 while inhibiting mtorc1 causing longevity
• Leucine
  
  • Most potent amino acid activator of mtorc1
• Mechanistic Target of Rapamycin
  
  • mtorc1
• Rapamycin
  
  • Decreases mtorc1 activity by binding to it